Archives
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It is possible that maternal separation
2022-01-21
It is possible that maternal separation-induced USV in neonatal rodents is not a good model of adult anxiety for examining GlyT1 inhibitors, if the expression levels of GlyT1, GlyA, and GlyB markedly differ between pups and adults. However, several reports provide evidence that this is not the case.
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FPG had no consistent activity in reducing
2022-01-21
FPG-2 had no consistent activity in reducing G→T transversions. Gao and Murphy [2] earlier reported that FPG-2 had a limited amount of activity in vitro on depurinated, UV-treated, and methylene-blue-treated DNA (but not on 8-oxo-G-containing oligonucleotides). FPG-2 contains the N-terminal domain a
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br Materials and methods br Results br Discussion
2022-01-21
Materials and methods Results Discussion Although large-scale purification of homogeneous and functional membrane proteins is challenging, it is essential for biochemical, biophysical and structural characterization. This is particularly true for human P-gp, as its atomic structure has only
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Glial cells have emerged as important
2022-01-21
Glial cells have emerged as important protagonists of the central nervous system (CNS) physiology (Chen and Swanson, 2003; Kettenmann and Verkhratsky, 2008; Parpura and Verkhratsky, 2012). As widely described in the literature, astrocytes regulate glutamatergic synapses by clearance of glutamate in
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Because of the relationship between
2022-01-21
Because of the relationship between carbohydrate consumption and chronic diseases such as obesity and type II diabetes (Hu, van Dam, & Liu, 2001), there is mounting interest to evaluate the quality of SGI-1027 through analysis by glycemic index (GI) and Englyst assay, for example (Englyst, Kingman,
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Ghrelin contains an n octanoylation
2022-01-21
Ghrelin contains an n-octanoylation at its Ser3 residue (Kojima et al., 1999). While des-acyl ghrelin is found in high concentrations in the blood, only the lipidated form is active at GHSR (Bednarek et al., 2000). We previously showed that ghrelin interacts with the membrane via its lipid modificat
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All data were analyzed using SAS
2022-01-21
All data were analyzed using SAS software (version 9.3, SAS Institute Inc., Cary, NC). Because of very low FFAR1 protein detection (at the detection limit or no signal) in 3 H-BHB cows, quantification was not possible within a linear range and therefore these animals were omitted from the statistica
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On the contrary the benzhydrol series showed
2022-01-21
On the contrary, the benzhydrol series showed modest activity with EC of two digit micromole. The bulkiness of the nos abbreviation sale tail may be the reason for the low activity. Interestingly, introduction of H-bonding groups, such as OMe in and CF in , slightly improved the activity compared to
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Epigenetic inheritance is regarded as the
2022-01-21
Epigenetic inheritance is regarded as the genetic modification of BAN ORL 24 that affects gene expression and related processes of other DNAs but does not directly change the DNA coding sequence [18]. Epigenetic inheritance includes DNA methylation, histone modification, and noncoding RNA expression
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BIIE 0246 Recently results obtained by our group
2022-01-21
Recently, results obtained by our group have demonstrated that hEECs are able to secrete NPY into the extracellular medium and that this peptide can induce an increase in the [Ca]i of these cells (Jacques et al., 2003b). In light of these results and those obtained in this study, we can speculate th
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GSK has also been used as PET radiotracer
2022-01-21
GSK-189254 has also been used as PET radiotracer (in the form of [11C]-GSK-189254, also used as [11C]-AZ12807110 by Jucaite et al. (Jucaite et al., 2013)) to assess H3R occupancy (Ashworth et al., 2010), and is currently used in an image-based phase I clinical trial study for investigating GSK-23951
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br Acknowledgments br Introduction The
2022-01-21
Acknowledgments Introduction The incidence of cholangiocarcinoma (CCA), a malignant tumor found in both intra- and extra-hepatic biliary epithelia [1], has been increased worldwide over the past two decades [2]. The prognosis of CCA patients are generally poor, due to the lack of early detecti
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The overall characteristic of RNA
2022-01-21
The overall characteristic of RNA profile of Leydig cell is still a mystery. Variation in total RNA will cause subsequent difference in protein expression and phenotypic modulation [16]. In this study, we used a murine nicotine exposure model coupled with next generation RNA sequencing (NGS) and fou
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On the other hand the single stranded RNA flavivirus hepatit
2022-01-21
On the other hand, the single-stranded RNA flavivirus hepatitis C virus (HCV), causes type C hepatitis, which often leads to liver cirrhosis, hepatic failure and hepatocellular carcinoma. Its genome of about 9.6kb encodes the structural proteins C, E1, E2, and the nonstructural proteins NS2, NS3, NS
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Considering the fact that OCL induced depletion of T cells
2022-01-20
Considering the fact that OCL induced depletion of T PYR-41 in non-stimulated cultures, the only possible explanation of this effect is the elevated mortality of these cells. It was found that OCL at the higher concentration induced the apoptosis of CD4+ and CD8+ T cells. These results strongly sug