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A few of the islet specific proteins identified in
2022-05-10
A few of the islet-specific proteins identified in the present study have previously been described in various contexts of pancreatic islets, i.e. PTPRN, SCG5, SCGN, SNAP25 and SNED1, validating the search algorithm applied and supporting the notion that also the novel proteins identified are indeed
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br Materials and methods br
2022-05-10
Materials and methods Acknowledgements The following reagents were obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH: SIVagm155-4 from Dr. Vanessa Hirsch and Dr. Philip Johnson; Anti-SIVmac251 Polyclonal; SIVagm tan-1 infectious molecular RO4987655 from Drs. Marcelo
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br Materials and methods br Results br Discussion
2022-05-10
Materials and methods Results Discussion Nervous system disease is an important signal of AIDS deterioration (Rosca et al., 2012, Yilmaz et al., 2012). It is possible that HIV crosses the blood exportin barrier or blood cerebrospinal fluid barrier into the central nervous system freely or
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Patient characteristics are presented in Serum oestradiol le
2022-05-10
Patient characteristics are presented in . Serum oestradiol levels on the day of oocyte retrieval or warming were higher in group A (253.2 pg/ml) compared with group B (192.6 pg/ml), despite a significantly reduced number of days (mean 3.5 days) taking oestrogens without the addition of progesterone
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br Material and methods br Results br Discussion The inhibit
2022-05-10
Material and methods Results Discussion The inhibitory action of a GABA agonist, muscimol, on the level of mRNA encoding GnRH in the POA-hypothalamus [25] of follicular-phase sheep has suggested that at the hypothalamic level GABA may exert a suppressive effect on subsequent steps of the Gn
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Recent studies revealed that synthetic oligomeric A decrease
2022-05-10
Recent studies revealed that synthetic oligomeric Aβ1-42 decreased GLT-1 expression and promoted mislocalization of GLT-1 from the cell surface of primary astrocytes, leading to glutamate dyshomeostasis in synapses (Abdul et al., 2009, Scimemi et al., 2013). To address the cause for reduction of as
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Shikonin represents naphtoquinonic compound isolated from th
2022-05-10
Shikonin represents naphtoquinonic compound isolated from the Chinese plant Lithospermum erythrorhizon[20]. Shikonin treatment inhibits AKT and ERK signaling pathways and induces apoptosis through FOXO transcription factors and mitochondrial pathway [21], [22]. Recent results suggest inhibition of l
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The expression of GLUT receptors throughout the body
2022-05-10
The expression of GLUT receptors throughout the body could be considered a potential source for off-target effects even for engineered glucose-conjugated nanomedicines, as there are at least 12 types of GLUT transporters in the body, including GLUT1 in erythrocytes and the blood-brain barrier, as we
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br Introduction Glucokinase GCK hexokinase IV
2022-05-09
Introduction Glucokinase (GCK, hexokinase IV) is a monomeric enzyme that catalyzes the ATP-dependent conversion of glucose to glucose 6-phosphate, the first and rate-limiting step of glycolysis in the liver and pancreas [1,2]. GCK was first discovered in the early 1960's, and shortly thereafter i
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A model substance often used in the
2022-05-09
A model substance often used in the studies of oxidative processes in erythrocytes is tert-butyl hydroperoxide (t-BHP), which, being lipophilic, passes easily across the erythrocyte membrane [9]. In erythrocytes treated with t-BHP (0.1–3mM) for less than 1h, a dramatic decline in the reduced glutath
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Our own search towards aryl imidazole derived GSMs
2022-05-09
Our own search towards aryl-imidazole derived GSMs led to the discovery of the benzimidazole derivative (). It is one of the most potent GSMs to date, suffering however from sub-optimal drug-like properties. More recently, we have described the design and synthesis of bicyclic triazolo-derivatives,
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Cepharanthine australia Our own search towards aryl imidazol
2022-05-09
Our own search towards aryl-imidazole derived GSMs led to the discovery of the benzimidazole derivative (). It is one of the most potent GSMs to date, suffering however from sub-optimal drug-like properties. More recently, we have described the design and synthesis of bicyclic triazolo-derivatives,
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Nano biocatalyst prepared by assembling an
2022-05-09
Nano-biocatalyst, prepared by assembling an enzyme on nanomaterial (NM) carriers is an emerging innovation in the field of nanobiotechnology. Some of the advantages of using NM as supports in GW-786034 to conventional porous supports are effective enzyme loading due to large surface area with reduc
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br Results and discussion br Conclusion In conclusion
2022-05-09
Results and discussion Conclusion In conclusion, twenty-one 4-monocyclic aryl-5-carbamoyl-3-isoxazolols have been synthesized and evaluated for their antagonistic activities against housefly and common cutworm GABARs expressed in Xenopus oocytes. The TEVC results indicated that Biotin-11-dUTP
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rna polymerase ii br Acknowledgements This work was supporte
2022-05-09
Acknowledgements This work was supported under the National Natural Science Foundation of China (Grant numbers 31200576, 21472197, 21675162), Beijing Natural Science Foundation (Grant No. 7182189), and Project supported by the Joint Funds of the National Natural Science Foundation of China (Grant
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