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The significant CRF increase in the
2021-04-19
The significant CRF increase in the DS and the overall changes in the CRF system observed in the VM and DS during the development of sensitization suggest that this neuropeptide (and possibly urocortin) contributes to the specific molecular alterations occurring in the mesolimbic pathway that suppo
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br System description and data collection Fig shows the arra
2021-04-19
System description and data collection Fig. 1 shows the arrangement of the system studied. It provided cooling auz synthesis to maintain thermal conditions in an institutional building. The locations of the measured variables (, and ) relating to temperature and flow rate are indicated in Fig. 1.
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Besides the assessment of toxicological effects
2021-04-19
Besides the assessment of toxicological effects immediately after exposure, we also studied the potential recovery of the exposed organisms, through the quantification of ChE activity at specific time intervals after placing organisms in clean test medium. Recovery from chemical challenge, in this c
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The proliferation of CCA cell lines can be
2021-04-19
The proliferation of CCA cell lines can be stimulated by estrogen and other growth factors (Alvaro et al., 2006; DeMorrow, 2009; Mancino et al., 2009). It has also been reported that estrogen positively modulates cholangiocyte proliferation, which is associated with cholangiopathies found in humans
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br Discussion Estradiol is known as one
2021-04-19
Discussion Estradiol is known as one of the stress signaling molecule [3,4,14]. Here, we showed that PH induced estradiol production before hepatocyte proliferation (Fig. 1). Conversely, the ovariectomized and orchitectomized mice produced less estradiol after PH, and had delayed liver regenerati
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Sampling sediments is usually performed with grab
2021-04-19
Sampling sediments is usually performed with grab corers [16], [29]. The digested sludge analyzed by Ternes et al. [16] was taken directly from the digester and the activated sludge was obtained by hedgehog signaling of the slurry of STPs [16]. Collected samples are transported under cooled conditio
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The Ewing sarcoma breakpoint region gene EWSR
2021-04-19
The Ewing sarcoma breakpoint region 1 gene (EWSR1) is a partner in a large, diverse range of mesenchymal (and some nonmesenchymal) tumors (Tables 1 and 2). As the 5′ partner, EWSR1 is able to fuse with an array of genes. These fusions can generate genetically different but phenotypically identical n
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br Halogenases Enzymatic C H activation
2021-04-19
Halogenases Enzymatic C–H activation leading to halogenation is another emerging area in biocatalysis [55,56]. Incorporation of halogen atoms during medicinal chemistry eff ;orts is a well-established practice, presenting an effective means to control the molecule’s bioactivity and physicochemical
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Tropical theileriosis is caused by
2021-04-19
Tropical theileriosis is caused by the apicomplexan parasite Theileria annulata which is transmitted by a tick vector from the genus Hyalomma in cattle (Echebli et al., 2014, Li et al., 2014). Theileria parasites invade the leukocytes by sporozoites secreted from the vector, schizonts mature into me
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br Results br Discussion Mucosal
2021-04-19
Results Discussion Mucosal barriers are constitutively challenged by various stimuli, and the homeostasis of mucosal barriers both at steady state and upon challenge are maintained by tissue-resident immune integrin signaling pathway (Kurashima et al., 2013, Okumura and Takeda, 2016). ILC3s a
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We found that Th cells derived either from in
2021-04-19
We found that Th17 cells, derived either from in vivo immunization or in vitro polarization under pathogenic conditions (in presence of IL-23 and/or IL-1β) expressed high levels of EBI2. In contrast, Th17 Sarpogrelate hydrochloride receptor that were generated in absence of IL-23 or IL-1β lost EBI2
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br Acknowledgements E B was supported
2021-04-19
Acknowledgements E.B. was supported by grant 16-34-60213 mol_a_dk from the Russian Foundation for Basic Research (RFBR). R.S. and A.V. were supported by grant of the President of Russian FederationMK-4253.2018.4. The work was performed according to the Russian Government Program of Competitive Gr
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In light of this our finding that
2021-04-19
In light of this, our finding that UBTD1 interacts with ubiquitin conjugating enzymes is intriguing. Using two different screening approaches, we have demonstrated that UBTD1 interacts with the ubiquitin conjugating E2D family proteins. Using purified recombinant proteins and gel filtration chromato
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br Results and Discussion br Conclusions Understanding the c
2021-04-19
Results and Discussion Conclusions Understanding the connections between function and fitness is a primary goal of many biological disciplines including systems biology and molecular evolution. While sound approaches have been developed to understand the connections between function and fitnes
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Until recently the first line
2021-04-19
Until recently, the first line treatment of RLS was the administration of low dose of three dopaminergic drugs, which has been approved by the US Food and Drug Administration and the European Medicines Agency for the treatment of moderate to severe RLS. These compounds are pramipexole (Mirapex), rop
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