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Despite the important agronomic traits regulated by SUMO mos
2021-03-12
Despite the important agronomic traits regulated by SUMO, most research studies on SUMOylation have been mainly limited to model plants, such as Arabidopsis and rice (Wang et al., 2011), due to the lack of molecular tools specific to other economically relevant plants. On the other hand, plants harb
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br Introduction DNA ligation is
2021-03-12
Introduction DNA ligation is required during DNA replication and to complete almost all DNA repair events. In human cells, the DNA ligases encoded by three LIG genes are responsible for joining interruptions in the phosphodiester backbone [1]. These enzymes have distinct but overlapping functions
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Regarding their reported beneficial properties on the digest
2021-03-12
Regarding their reported beneficial properties on the digestive tract, the aim of this study was to evaluate the effect of water extracts of three Hypericum sps., HP, HA, HU and some of the main phenolic compounds (Ch, R and Q) on DNA protection against oxidative and alkylating DNA damage induced by
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Herein we report the expression
2021-03-11
Herein we report the expression of shrimp Cdk-2 in hepatopancreas, gills and muscle, finding higher expression in hepatopancreas and gills and lower expression in muscle. No significant changes due to hypoxia and hypoxia reoxygenation were detected on the expression of Cdk-2 in hepatopancreas and gi
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br Conflicts of interest br
2021-03-11
Conflicts of interest Acknowledgements Lung cancer continues to be the leading cause of cancer deaths in the US and worldwide., Non–small-cell lung cancer (NSCLC) remains the predominant form of lung cancer (approximately 85%)., With some improvements in surgical techniques and combined the
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br System description and data
2021-03-11
System description and data collection Fig. 1 shows the arrangement of the system studied. It provided cooling gsk3 inhibitor to maintain thermal conditions in an institutional building. The locations of the measured variables (, and ) relating to temperature and flow rate are indicated in Fig. 1
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As demonstrated by Mak and colleagues ER is known to
2021-03-11
As demonstrated by Mak and colleagues, ERβ is known to be a part of the NFκB-HIF-1α signaling pathway during hypoxia as well as chronic inflammation of prostate (Mak et al., 2015), therefore in the next part of the study, we evaluated whether ZEA-induced ROS production is also associated with NFκB-H
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In the frontal cortex the present study
2021-03-11
In the frontal cortex, the present study found a relationship between working memory performance and activated Erk2 expression for the E2-only group, where animals that tended to perform better on the WMC measure tended to have higher activated Erk2 expression. This suggests that there is a unique r
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Introduction Primitive neuroectodermal tumors PNETs are
2021-03-11
Introduction Primitive neuroectodermal tumors (PNETs) are malignant, small round cell tumors of neural crest origin which typically arises from bone or soft tissue in the trunk/axial skeleton/paraspinal regions in adolescents and young adults and comprises of 50% cases with local recurrence and met
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In terms of its protease activity
2021-03-11
In terms of its protease activity, MME has a broad range of substrates being able to target glucagon, bradykinin, GLP1, and several other PF-543 of circulating small molecules [25]. MME has been shown to target free insulin B-chain [32], although whether MME could target and degrade the insulin rec
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In conclusion our findings demonstrated that S
2021-03-11
In conclusion, our findings demonstrated that S1PC augments HMOX1 expression in a NO-dependent manner, and its effects are associated with the enhancement of BACH1 degradation. In addition, S1PC and NO potentially degrade BACH1 based on the observation that nuclear degradation of BACH1 differs from
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At present there have been relatively few studies
2021-03-11
At present, there have been relatively few studies that evaluated potential correlations between pulmonary and pleura metastases, hilar and mediastinal Senegenin mg nodes, and organs associated with distant metastasis and EGFR mutations [33,34,37]. Further research on these relationships is needed,
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In an effort to discover additional GPCRs directing the migr
2021-03-11
In an effort to discover additional GPCRs directing the migratory events of responding B cells, we identified Epstein-Barr virus (EBV)-induced gene 2 (EBI2) as a promising candidate. The gene encoding EBI2 (Ebi2, also known as Gpr183) was originally identified together with Ebi1 (Ccr7) as the most h
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Lithocholic Acid br Acknowledgements The study of RING type
2021-03-11
Acknowledgements The study of RING-type E3s continues to grow extremely rapidly. We regret that it was possible to only cite a fraction of the outstanding primary publications in this field. This work was supported by the National Institute of General Medical Sciences grants R01 GM088055 and R01
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Of the acidic hydroxyazoles involved hydroxypyrazole had the
2021-03-11
Of the acidic hydroxyazoles involved, hydroxypyrazole had the weakest acidic profile (pKa in the range of 6–7), although highly deprotonated at physiological pH. During hit optimization, the two pyrazole ring positions available for substitution provide an opportunity for a better exploration of the
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