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br Structure of USP Schematic representation of
2019-08-19
Structure of USP7 Schematic representation of the USP7 domain architecture is shown in Fig. 3B. USP7 is a 135 kDa protein that consists of seven domains, including the N-terminal TRAF-like (Tumor necrosis factor Receptor–Associated Factor) domain, followed by the catalytic core domain and the fiv
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The monomeric oligomeric states of DDR V His
2019-08-19
The monomeric/oligomeric states of DDR2-V5-His and DDR2-Fc were confirmed by Western blotting under reducing and non-reducing conditions. As shown in Fig. 1b, DDR2-V5-His exhibited a relative molecular mass of ~60 kDa under both reducing and non-reducing conditions, consistent with this protein bein
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br Assessing DUB activity The Ub
2019-08-19
Assessing DUB activity The Ub field has benefited greatly from the past efforts of biochemists and chemical biologists who have reconstituted Ub signals in vitro and generated tools for capturing or measuring DUB activities, many of which can be readily produced or are commercially available (Ekk
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A number of studies have been carried out to understand
2019-08-19
A number of studies have been carried out to understand lipid production pathways and to increase TAGs level in higher plants. Overexpression of key aromatase inhibitor of the Kennedy pathway until now is by far the most successful strategy to increase TAG lipid content in Brassica napus, Arabidops
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An increasing body of evidence demonstrates that MXC can
2019-08-19
An increasing body of evidence demonstrates that MXC can cause neurobehavioral and neuropathological alterations [7]. In the brain, there are several steroidogenic enzymes, which are responsible for neurosteroid production. Neurosteroids are subsets of steroids that rapidly change neuronal excitabil
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br Materials and methods br Results br Discussion Recently
2019-08-19
Materials and methods Results Discussion Recently, circRNAs have been found to play important diagnostic or prognostic roles in different tumors. For example, aberrant expression levels of different circRNAs are found in ovarian cancer, lung cancer, renal cancer, gastric cancer and particip
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br Materials and methods br Results br Discussion Although n
2019-08-19
Materials and methods Results Discussion Although no increase in DAPK activity was detected at early time points associated with neuronal apoptosis, it is possible that the spread of apoptosis through the Org 25543 following HI is not synchronized enough to yield a large, consistent fluctu
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This study had some limitations First a small
2019-08-19
This study had some limitations. First, a small number of HP patients were enrolled because of the extreme rarity of this disease, which may have caused some selection bias. Yokoseki et al., found no increase in Th2 cytokines, such as IL-4, in IHP patients (Yokoseki et al., 2014). The sensitivity of
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For the first time the V carinata transcriptome was
2019-08-19
For the first time, the V. carinata transcriptome was analyzed and its transcript coding sequences comprehensively characterized. The non-redundant contigs encoding putative CysPs were identified and their methosulfate to patterns in different tissues were investigated. Our study show that four pro
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The significance of the difference
2019-08-17
The significance of the difference in the DDR2 binding specificity towards fibrillar and non-fibrillar collagens is not understood, but may imply differences in biological responses when chondrocytes bind to different collagens in the growth plate. Investigations by Labrador et al. (2001) have shown
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The chemical structures of I C MOI and
2019-08-17
The chemical structures of I3C, 3MOI, and 3MI and the pd0325901 responsible for 3MI metabolism in rainbow trout and carp are shown in Fig. 4. Discussion To determine the individual CYP450 isoforms involved in 3MI metabolism, we used specific inhibitors for CYP1A, CYP3A and CYP2E1. Our results su
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In summary we elucidated the in vitro
2019-08-17
In summary, we elucidated the in vitro activities of KDM1B in regulation of PC cell proliferation and apoptosis. These studies provided a novel insight into the previously unrecognized roles of KDM1B in human PC cells. We showed for the first time that KDM1B knockdown attenuated proliferation and in
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br Materials and methods br Results The BUN and
2019-08-17
Materials and methods Results The BUN and creatinine levels in the saline-treated CRF group were found to be significantly higher than those in the sham-operated control rats treated with either montelukast or saline (pand such as tissues, were found to be significantly higher in the saline-tr
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We have previously reported that CK is downregulated in sene
2019-08-17
We have previously reported that CK2 is downregulated in senescent human lung fibroblast IMR-90 cells, aged rat tissues, and aging nematodes [17,18]. CK2 downregulation induces cellular senescence via the PI3K-AKT-mTOR-reactive oxygen species-p53-p21Cip1/WAF1 pathway in human cells [[19], [20], [21]
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br Acknowledgements This work was supported in part by JSPS
2019-08-17
Acknowledgements This work was supported in part by JSPS KAKENHI Grant Number 26292031. Introduction The Cys-loop receptors constitute an important superfamily of ligand-gated ion Harringtonine calculator (LGICs) and mediate synaptic transmission in both invertebrate and vertebrate nervous sy
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