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br Experiment br Results and
2024-04-18
Experiment Results and discussion Conclusion Introduction Tuberculosis (TB) is a chronic specific bacterial infection caused by bacteria of the Mycobacterium tuberculosis [1]. TB remains one of the deadliest diseases in the world. It is the second leading infectious cause of death after
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With the treatment options available today including a combi
2024-04-18
With the treatment options available today including a combination of symptomatic treatments and general immunosuppression, many MG patients can lead productive lives [1], [4], [20]. The frequency of death has decreased due to improved management and detection of milder cases. At present, the overal
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br Materials and methods br Results br Discussion Prostate c
2024-04-18
Materials and methods Results Discussion Prostate cancer represents an ideal candidate for chemoprevention because of its high incidence and long latency to clinically significant disease [17]. The precancerous lesion PIN may also be a suitable target for ablation in chemoprevention strateg
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Immunology Compound Library It has been reported that leukot
2024-04-18
It has been reported that leukotrienes and their receptors, e.g. the cysteinyl leukotriene receptor 1 (CysLT1) may promote Immunology Compound Library injury (Ding et al., 2007) and that increased 5-LOX expression and activity lead to production of brain-toxic molecules (Khan et al., 2010). However
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During myeloid cell maturation expression of LO mRNA and
2024-04-18
During myeloid cell maturation, expression of 5-LO mRNA and protein is strongly induced (60–130-fold) by calcitriol (1,25(OH)2D3) and transforming growth factor-β (TGFβ) [6,7]. The upregulation of 5-LO mRNA transcription is mainly due to transcript elongation and mRNA maturation [8,9]. Interestingly
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NKY 80 The c C T mutation identified
2024-04-18
The c.286C>T mutation identified in subject K20-1 was also reported in other ethnic groups, including Brazilian, French-Canadian, Italian, and Arabs from the United Arab Emirates [20], [21], [22], whereas c.318A>G mutation in subjects K10-1 was previously reported in Asian and Caucasians [13], [23],
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MafB a member of the Maf
2024-04-18
MafB, a member of the Maf protein family, is essential for terminal differentiation of macrophages (Kelly et al., 2000). The phagocytic activity of polystyrene beads was found to be enhanced in Curcumol with exogenous expression of MafB (Tillmanns et al., 2007). However, in alveolar macrophages of
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Recent progress has been made in
2024-04-17
Recent progress has been made in translating animal findings on memory performance and amnestic effects – that are largely determined by tonically active receptors in which α5 contributes to the benzodiazepine binding site. Based on the observation that deletion of this subunit led to improved spati
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PD research involves the use of many animal models which
2024-04-17
PD research involves the use of many animal models, which can be categorized into two main types: toxic models—among which the two most widely used are the classical 6-hydroxydopamine (6-OHDA) model in rats and the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model in mice and monkeys—and gen
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neurokinin receptor Introduction Hepatocellular carcinoma HC
2024-04-17
Introduction Hepatocellular carcinoma (HCC) is one of the most difficult cancers to treat, and it threatens human health severely [1]. Although various interventions, including surgical operation, radiofrequency ablation, and chemotherapy, have been endorsed, the prognosis of HCC patients remains p
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br ROS in AiP and regeneration
2024-04-17
ROS in AiP and regeneration Tissue wounding and inflammation are associated with production of ROS, and recent studies show that generation of ROS, especially during the initial stages of wounding and regeneration are essential for an efficient wound healing response. ROS, in particular H2O2 func
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Ethacrynic Acid receptor There are several AP binding sites
2024-04-17
There are several AP-1 Ethacrynic Acid receptor in the sequence of TIMP-1 promoter [18,19]. EBV could up-regulate TIMP-1 expression by binding to the AP-1 site in the TIMP-1 promoter [18]. IL-32, a newly multi-function cytokine, could activate AP-1, NF-κβ, p38MAPK signal pathways, and induce cytoki
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There are several AP binding sites in
2024-04-17
There are several AP-1 β-Funaltrexamine hydrochloride synthesis in the sequence of TIMP-1 promoter [18,19]. EBV could up-regulate TIMP-1 expression by binding to the AP-1 site in the TIMP-1 promoter [18]. IL-32, a newly multi-function cytokine, could activate AP-1, NF-κβ, p38MAPK signal pathways, a
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enzastaurin To investigate if WP increased CAT activity in c
2024-04-17
To investigate if WP increased CAT activity in cells, C2C12 muscle enzastaurin were treated with 0.1 to 0.4 mg/mL of WP (80.05% protein) for 24 h and then stressed with 0.75 mM H2O2 for 1 h (Xu et al., 2011). The CAT activity was significantly enhanced from 15.1 ± 0.7 to 23.7 ± 1.3 U/mg of total ce
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On the contrary Birrel and colleagues observed divergent
2024-04-17
On the contrary, Birrel and colleagues observed divergent proliferative responses to androgens in different BC cell lines: DHT and mibolerone were found to inhibit the T47-D and ZR-75-1 AZD0530 australia growth, while the proliferation of MCF-7 cells was increased by both the androgens [53]. It is
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